I think the neighborhood could most profit from a dedicated coffeeshop/cafe and a dedicated wine bar.
On a smaller scale, I think a pet amenities shop or a bike/running store might do well.
I'd love to see a butcher shop, but that's probably a product of a bygone era.
I like the idea someone mentioned about a brewery, but I don't see that this building has space that would work. I remember when Carolina Brewery had their bar upstairs at 1111 Central, that was a great place.